Metronidazole Injection

Additional Details

Composition :

Each 100ml contains:

Metronidazole 500 mg

Sodium Chloride 0.8%w/v

Water for Injecion q.s

INDICATIONS & DOSAGES : 

Anaerobic Infections:

Adult: 500mg infused as100ml of a 5 mg/ml solution at 5 ml/min 8 hrly.

Alternatively,15 mg/kg infusion followed by 7.5 mg/kg infusion followed by 7.5 mg/kg 6 hrly; infuse over 1 hr(max ; 4gm in 2 hr).Subtitute oral therapy as soon as possible.

Child: 7.5 mg/kg 8 hrly. Elderly :use lower end of adult dose recommendations. Do not admin as single dose.

PREVENTION OF POST OPERATIVE ANAEROBIC BACTERIAL INFECTIONS:

Adult 500 mg by IV infusion shortly before operation and repeated hrly; oral doses of 200 mg or 400 mg 8 hrly being substitute as soon as possible. Patient undergoing colorectal surgery; 15mg/kg infused over 30 -60 min, completed about 1 hr prior to surgery, followed by 2 further IV doses of 7.5 mg/kg  infused at 6 and 12 hr after the initial dose.

Elderly : Use lower end of adult dose recommendations . Do not admin as single dose.

CONTRA-INDICATIONS: Neurological disease, blood dyscrasias, fist trimester of pregnancySIDE-EFFECTS: Anorexia, nausea metallic taste, abdominal cramps headache,glossitis, dryness of mouth, dizziness, peripheral neuropathy, CNS effects, seizures. Thromboflebitis of injected vein.